Article

Systematic De-Risking of TCR-Mimic Therapeutics Through Proteome-Wide Off-Target Landscaping and a Generalizable Design Rule Framework

2026-08-04

Abstract excerpt

<h4>ABSTRACT</h4> TCR-mimic (TCRm) antibodies targeting peptide-human leukocyte antigen (pHLA) complexes enable precision immunotherapy against intracellular antigens, including cancer-testis antigens (CTAs). Achieving high specificity, however, remains challenging because of the vast diversity of the human immunopeptidome and the associated risk of off-target recognition. Here, we introduce ValidaTe, a unified f...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: da6860c0-5917-530c-855d-a936147d4811
DOI: 10.64898/2026.07.30.741432

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Systematic De-Risking of TCR-Mimic Therapeutics Through Proteome-Wide Off-Target Landscaping and a Generalizable Design Rule FrameworkDOI 10.64898/2026.07.30.741432Read

EpiTox: A Multi-Modular Framework for Population-Aware Off-Target Prediction Highlighting MAGEA3 Cross-ReactivitySemantic proximity Read

Contextualising the developability risk of antibodies with lambda light chains using enhanced therapeutic antibody profilingSemantic proximity Read

A generalizable system for antigenic peptide targeting across HLA-I allotypesSemantic proximity Read

A systematic safety pipeline for selection of T-cell receptors to enter clinical useSemantic proximity Read

Predicting TCR antigen specificity at proteome-scale with synthetic immune cells and machine learningSemantic proximity Read

Discovery 4.0: An Escape-Aware Computational Platform for Resistance-Proofed Chimeric Antigen Receptor DesignSemantic proximity Read

Immunogenicity of Therapeutic Antibodies: Mechanisms, Prediction, and Mitigation Strategies in the Era of Personalized BiologicsSemantic proximity Read

PCI-DB: A novel primary tissue immunopeptidome database to guide next-generation peptide-based immunotherapy developmentSemantic proximity Read

De novo designed pMHC binders facilitate T cell induced killing of cancer cellsSemantic proximity Read

Automating neoantigen selection for personalized cancer vaccine designSemantic proximity Read

Multi-strategies embedded framework for neoantigen vaccine maturationSemantic proximity Read

Computationally profiling peptide:MHC recognition by T-cell receptors and T-cell receptor-mimetic antibodiesSemantic proximity Read