Article

Design of high specificity binders for peptide-MHC-I complexes

2024-11-28

Abstract excerpt

Class I MHC molecules present peptides derived from intracellular antigens on the cell surface for immune surveillance, and specific targeting of these peptide-MHC (pMHC) complexes could have considerable utility for treating diseases. Such targeting is challenging as it requires readout of the few outward facing peptide antigen residues and the avoidance of extensive contacts with the MHC carrier which is present...

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Literature Corpus work: 824a4d59-0b4d-5cfc-82b6-fad20b887f41
DOI: 10.1101/2024.11.28.625793

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