Article

Acetyl-CoA Carboxylase Obstructs CD8 <sup>+</sup> T-Cell Lipid Utilization and Energy Synthesis in the Tumor Microenvironment

2023-11-17

Abstract excerpt

<h4>Summary</h4> The solid tumor microenvironment (TME) imprints a compromised metabolic state in tumor infiltrating T cells (TILs) hallmarked by the inability to maintain effective energy synthesis for antitumor function and survival. T cells in the TME must catabolize lipids via mitochondrial fatty acid oxidation (FAO) to supply energy in nutrient stress, and it is established that T cells enriched in FAO are a...

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Literature Corpus work: aefc7762-0a7c-563f-b4fb-53b8ea98b06b
DOI: 10.1101/2023.11.16.567439

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