Article

Pyruvate metabolism controls epigenome remodeling during CD4+ T cell activation

2022-02-14

Abstract excerpt

<title>Abstract</title> <p>Upon antigen-specific T Cell Receptor (TCR) engagement, human CD4+ T cells proliferate and differentiate, a process associated with rapid transcriptional changes and metabolic reprogramming. Here, we show that generation of extra-mitochondrial pyruvate is an essential step for acetyl-CoA production and subsequent H3K27ac-mediated epigenome remodeling. In contrast, neither acetate/ACSS2...

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Literature Corpus work: 96c6b920-5393-5207-9ec8-de4364d279b8
DOI: 10.21203/rs.3.rs-1324599/v1

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