Article

The mitochondrial thiolase ACAT1 regulates monocyte/macrophage type I interferon <i>via</i> epigenetic control

2024-01-31

Abstract excerpt

<h4>ABSTRACT</h4> Lipid-derived acetyl-CoA is shown to be the major carbon source for histone acetylation. However, there is no direct evidence demonstrating lipid metabolic pathway contribututions to this process. Mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) catalyzes the final step of ß-oxidation, the aerobic process catabolizing fatty acids (FA) into acetyl-CoA. To investigate this in the context of im...

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Literature Corpus work: e18e561f-2c1e-59a8-9a0b-926a5c13d469
DOI: 10.1101/2024.01.29.577773

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