Article

Active aldehydes accelerate CD8+ T cell exhaustion through metabolic alteration in tumor microenvironment

2024-10-11

Abstract excerpt

<title>Abstract</title> <p>Glycolysis and mitochondrial fatty acid oxidation (FAO) regulate CD8+ T cell differentiation fate. However, how glycolysis and FAO balance are associated with T-cell exhaustion remains unknown. PD-1 signal inhibits glycolysis and enhances FAO. We find that CD8+ T cells in the tumors adhered to glycolysis with attenuated FAO despite high PD-1 expression, which was defined as “metabolic e...

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Literature Corpus work: f6e186e7-c9f9-5638-a686-65ecc632710f
DOI: 10.21203/rs.3.rs-5222296/v1

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