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Alterations in PD-L1 succinylation shape anti-tumor immune responses in melanoma

1 Mar 2025

Abstract excerpt

Tumors undergo metabolic reprogramming to meet the energetic, synthetic and redox demands essential for malignancy, often characterized by increased glycolysis and lactate production. However, the role of mitochondrial metabolism in tumor immunity remains unclear. The present study integrates spatial transcriptomics, bulk transcriptomics and proteomics, revealing a strong link between the metabolite succinyl-CoA...

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PMID: 40069506
DOI: 10.1038/s41588-025-02077-6

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