Article

Divergent role of CD8 T cells with distinct metabolic phenotypes during curative radio-immunotherapy in hot versus cold tumors

2025-10-26

Abstract excerpt

<h4>ABSTRACT</h4> Immunotherapy has potential for impactful cancer cures by empowering patients’ own immune cells. We developed a radio-immunotherapy regimen that can cure large immunologically hot and cold murine tumors. Here, we explored the divergent role of CD8 T cells during this radio-immunotherapy in contrasting hot colon carcinoma versus cold melanoma. We introduced an immunocompetent mouse model with mCh...

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Literature Corpus work: 528da7f5-92a5-5a5b-93cf-3387dd241acd
DOI: 10.1101/2025.10.24.684274

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