Article

AADAT-Driven Metabolic Control of Malate and CoQ <sub>10</sub> Shapes Immune Evasion in Triple-Negative Breast Cancer

2026-01-30

Abstract excerpt

Compared to other subtypes of breast cancer, triple-negative breast cancers (TNBC) have fewer treatment options and exhibit a worse prognosis. Through integrated transcriptomic, metabolomic, immunohistochemical, spatial, and clinical analyses, we identify the mitochondrial enzyme, α-aminoadipate aminotransferase (AADAT) as a previously unrecognized metabolic immune checkpoint in TNBC. AADAT mRNA and protein were...

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Literature Corpus work: dd2c3d4f-fe32-548e-8f6c-a7fbb3cd2212
DOI: 10.64898/2026.01.28.702389

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