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The pivotal role of metabolism in shaping tumor-associated macrophages phenotype and function.

International immunopharmacology - 15 May 2026

Jun Mei, Li Tiantian, Shi Yilin, Yin Hang, Wu Wenjie, Dong Xinmin, He Xigetu, Lai Xiong

Abstract excerpt

Tumor progression is critically shaped by the dynamic interplay between tumor cells and the tumor microenvironment (TME). The TME harbors a diverse array of immune cells, encompassing T cell, B cell, NK cell and macrophages. Among these, TAMs profoundly shape tumor growth and metastasis by interacting with tumor cells and other immune cells. To adapt to the varied immune and metabolic cues in the TME, they...

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Identifiers

PMID: 41875496
DOI: 10.1016/j.intimp.2026.116547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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