Article

Integrated genomic analysis and CRISPRi implicates<i>EGFR</i>in Alzheimer’s disease risk

2025-06-26

Abstract excerpt

Genome-wide association studies (GWAS) have identified numerous loci linked to late-onset Alzheimer’s disease (LOAD), but the pan-brain regional effects of these loci remain largely uncharacterized. To address this, we systematically analyzed all LOAD-associated regions reported by Bellenguez et al. using the FILER functional genomics catalog across 174 datasets, including enhancers, transcription factors, and qua...

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Literature Corpus work: fc735a8d-be2d-59e8-a23a-9aaaf5f53b28
DOI: 10.1101/2025.06.25.25328705

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