Article

<i>NF2</i> loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under environmental stress

2025-05-03

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic ductal adenocarcinoma (PDAC) occurs as a complex, multifaceted event driven by the interplay of tumor permissive genetic mutations, nature of cellular origin and microenvironmental stress. In this study, using primary human pancreatic acinar 3D organoids, we performed CRISPR knockout screen targeting 199 previously underappreciated potential tumor suppressors curated from clinical PDA...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ae95623c-c33a-5bf3-b308-92d9531c6621
DOI: 10.1101/2025.04.29.651251

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>NF2</i> loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under environmental stressDOI 10.1101/2025.04.29.651251Read

NF1 loss of function as an alternative initiating event in pancreatic ductal adenocarcinoma.Semantic proximity Read

Transcriptome Landscape of Cancer‐Associated Fibroblasts in Human PDACSemantic proximity Read

NFATC2 in pancreatic cancer-associated fibroblasts predicts treatment response and facilitates ERBB-targeted therapiesSemantic proximity Read

Myc instructs and maintains pancreatic adenocarcinoma phenotypeSemantic proximity Read

Spatial drivers and pre-cancer populations collaborate with the microenvironment in untreated and chemo-resistant pancreatic cancerSemantic proximity Read

Large-scale multi-omic analysis identifies noncoding somatic driver mutations and nominates<i>ZFP36L2</i>as a driver gene for pancreatic ductal adenocarcinomaSemantic proximity Read

Differential Activity of MAPK signalling Defines Fibroblast Subtypes in Pancreatic CancerSemantic proximity Read

MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype.Semantic proximity Read

Hypoxia-induced histone methylation and NF-κB activation in pancreas cancer fibroblasts promote EMT-supportive growth factor secretionSemantic proximity Read

Adaptation to ARF6-depletion in KRAS-driven PDAC is abolished by targeting TLR2Semantic proximity Read

Invasion status stratifies the composition of the human pancreatic cancer perineural nicheSemantic proximity Read

An autochthonous CRISPR activation screening platform for characterizing tissue-specific oncogene selection.Semantic proximity Read