Article

Hypoxia-induced histone methylation and NF-κB activation in pancreas cancer fibroblasts promote EMT-supportive growth factor secretion

2025-02-05

Abstract excerpt

<h4>ABSTRACT</h4> The pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment contains hypoxic tissue subdomains and cancer-associated fibroblasts (CAFs) of multiple subtypes that play tumor-promoting and -restraining roles. Here, we demonstrate that hypoxia promotes an inflammatory-like CAF phenotype and that hypoxic CAFs selectively promote epithelial-mesenchymal transition (EMT) in PDAC cancer cells thr...

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Literature Corpus work: 2aa00649-873b-5b25-8e64-28b3dd5391c5
DOI: 10.1101/2025.01.30.635486

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