Article

Spatial drivers and pre-cancer populations collaborate with the microenvironment in untreated and chemo-resistant pancreatic cancer

2021-01-14

Abstract excerpt

<h4>SUMMARY</h4> Pancreatic Ductal Adenocarcinoma (PDAC) is a lethal disease with limited treatment options and poor survival. We studied 73 samples from 21 patients (7 treatment-naïve and 14 treated with neoadjuvant regimens), analyzing distinct spatial units and performing bulk proteogenomics, single cell sequencing, and cellular imaging. Spatial drivers, including mutant KRAS , SMAD4 , and GNAQ, were associ...

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Identifiers and source

Literature Corpus work: 777fded3-fa68-5507-b8a9-029a6bc1bca0
DOI: 10.1101/2021.01.13.426413

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