Article

Myc instructs and maintains pancreatic adenocarcinoma phenotype

2019-02-21

Abstract excerpt

<h4>SUMMARY</h4> Pancreatic ductal adenocarcinoma (PDAC) is characterized by its dismal prognosis and its signature fibroinflammatory phenotype. We show that activation of Myc in PanIN epithelial cells is alone sufficient to instruct and maintain immediate transition of indolent PanINs to PDACs phenotypically identical to the spontaneous human disease. Myc does this by inducing a distinct, tissue-specific ensembl...

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Literature Corpus work: b6701700-1405-5fe8-9326-5f36d55887c5
DOI: 10.1101/556399

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