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NFATC2 in pancreatic cancer-associated fibroblasts predicts treatment response and facilitates ERBB-targeted therapies

2026-04-07

Abstract excerpt

<h4>SUMMARY</h4> Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy, with therapeutic resistance influenced by a dense desmoplastic stroma dominated by cancer-associated fibroblasts (CAF). Using single-cell RNA-sequencing and gene regulatory network modeling of 42 PDAC tumors, we identified a CAF subpopulation characterized by elevated NFATC2 expression that is enriched in patients with improved...

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Literature Corpus work
2d2272aa-471c-5da4-8f0b-a18ca9fbf9e8
DOI
10.64898/2026.04.04.716465
Open publication

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NFATC2 in pancreatic cancer-associated fibroblasts predicts treatment response and facilitates ERBB-targeted therapiesDOI 10.64898/2026.04.04.716465
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