Large-scale multi-omic analysis identifies noncoding somatic driver mutations and nominates<i>ZFP36L2</i>as a driver gene for pancreatic ductal adenocarcinoma

Abstract excerpt

Identification of somatic driver mutations in the noncoding genome remains challenging. To comprehensively characterize noncoding driver mutations for pancreatic ductal adenocarcinoma (PDAC), we first created genome-scale maps of accessible chromatin regions (ACRs) and histone modification marks (HMMs) in pancreatic cell lines and purified pancreatic acinar and duct cells. Integration with whole-genome mutation ca...

Topics

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• DNA Mutational Analysis
• Gene Expression Regulation, Neoplastic
• Mutation
• Neoplasms
• Oncogenes
• Promoter Regions, Genetic
• Regulatory Sequences, Nucleic Acid
• X-Box Binding Protein 1

Identifiers and source

Literature Corpus work

e335e3d0-9315-5f14-8048-0ad8fe2c20a5

DOI

10.1101/2024.09.22.24314165