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Transcriptome Landscape of Cancer‐Associated Fibroblasts in Human PDAC

28 Feb 2025

Abstract excerpt

Abstract Cancer‐associated fibroblasts (CAFs) play a crucial role in the progression of pancreatic ductal adenocarcinoma (PDAC). Here, integrated single‐cell RNA sequencing analysis is utilized to comprehensively map CAFs in the human PDAC tumor microenvironment (TME). Normal fibroblasts (NFs) and nine distinct CAF subtypes are identified including newly identified CAF subtypes, CDCP1 + FTL + CAFs, transitional...

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PMID: 40019403
DOI: 10.1002/advs.202415196

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