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Invasion status stratifies the composition of the human pancreatic cancer perineural niche

2026-08-06

Abstract excerpt

The peripheral nervous system innervates the pancreatic ductal adenocarcinoma (PDAC) microenvironment, and perineural invasion (PNI), the invasion of cancer cells in and around nerves, correlates with metastatic burden and poor outcomes. Though PDAC innervation is near universal and the majority of PDAC patients harbor PNI, the cellular and molecular composition of the heterocellular perineural niche is largely un...

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Literature Corpus work
a9db0b97-dee3-5d7d-b5d4-74b915925ce6
DOI
10.64898/2026.08.05.743048
Open publication

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Invasion status stratifies the composition of the human pancreatic cancer perineural nicheDOI 10.64898/2026.08.05.743048
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