Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype.

Cancer discovery - 1 Apr 2020

Sodir Nicole M, Kortlever Roderik M, Barthet Valentin J A, Campos Tania, Pellegrinet Luca, Kupczak Steven, Anastasiou Panayiotis, Swigart Lamorna Brown, Soucek Laura, Arends Mark J, Littlewood Trevor D, Evan Gerard I

Abstract excerpt

The signature features of pancreatic ductal adenocarcinoma (PDAC) are its fibroinflammatory stroma, poor immune activity, and dismal prognosis. We show that acute activation of Myc in indolent pancreatic intraepithelial neoplasm (PanIN) epithelial cells in vivo is, alone, sufficient to trigger immediate release of instructive signals that together coordinate changes in multiple stromal and immune-cell types and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Pancreatic Ductal
Share to Genes, myc

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pancreatic Neoplasms

Share to Phenotype

Share to Prognosis

Share to Proto-Oncogene Proteins c-myc

Share to Proto-Oncogene Proteins p21(ras)

Source

Identifiers

PMID: 31941709
DOI: 10.1158/2159-8290.CD-19-0435

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype.PMID 31941709Read ↗

Myc instructs and maintains pancreatic adenocarcinoma phenotypeSemantic proximity Read ↗

Deconstructing Pancreatic Adenocarcinoma by Targeting the Conductor, MYC.Semantic proximity Read ↗

From precursor to cancer: decoding the intrinsic and extrinsic pathways of pancreatic intraepithelial neoplasia progression.Semantic proximity Read ↗

Oncogenic signaling pathways in pancreatic ductal adenocarcinoma.Semantic proximity Read ↗

DNA methylation memory of pancreatic acinar-ductal metaplasia transition state altering Kras-downstream PI3K and Rho GTPase signaling in the absence of Kras mutation.Semantic proximity Read ↗

Combined MEK and STAT3 inhibition reprograms stromal inflammation to overcome immunotherapy resistance in pancreatic cancerSemantic proximity Read ↗

The reciprocal regulation between host tissue and immune cells in pancreatic ductal adenocarcinoma: new insights and therapeutic implicationsSemantic proximity Read ↗

A mucus production programme promotes classical pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Distinct mechanisms of innate and adaptive immune regulation underlie poor oncologic outcomes associated with KRAS-TP53 co-alteration in pancreatic cancer.Semantic proximity Read ↗

Distinct Mechanisms of Innate and Adaptive Immune Regulation Underlie Poor Oncologic Outcomes Associated with <i>KRAS-TP53</i> Co-Alteration in Pancreatic CancerSemantic proximity Read ↗

Myc inhibition triggers GM-CSF-driven regression of pancreatic tumoursSemantic proximity Read ↗

Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.