Article

Adaptation to ARF6-depletion in KRAS-driven PDAC is abolished by targeting TLR2

2023-12-02

Abstract excerpt

<h4>SUMMARY</h4> Metastasis is responsible for nearly 90% of all cancer-related deaths. Despite global efforts to prevent aggressive tumours, cancers such as pancreatic ductal adenocarcinoma (PDAC) are poorly diagnosed in the primary stage, resulting in lethal metastatic disease. RAS mutations are known to promote tumour spread, with mutant KRAS present in up to 90% of cases. Until recently, mutant KRAS remained...

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Literature Corpus work: b8998475-ee6d-5099-9053-f68968d2373a
DOI: 10.1101/2023.11.30.569405

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