NF1 loss of function as an alternative initiating event in pancreatic ductal adenocarcinoma.

doi:10.1016/j.celrep.2022.111623

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Article

NF1 loss of function as an alternative initiating event in pancreatic ductal adenocarcinoma.

Cell reports - 8 Nov 2022

Ramakrishnan Gopalakrishnan, Parajuli Parash, Singh Pura, Friend Creighton, Hurwitz Eric, Prunier Celine, Razzaque Mohammed S, Xu Keli, Atfi Azeddine

Abstract excerpt

A long-standing question in the pancreatic ductal adenocarcinoma (PDAC) field has been whether alternative genetic alterations could substitute for oncogenic KRAS mutations in initiating malignancy. Here, we report that Neurofibromin1 (NF1) inactivation can bypass the requirement of mutant KRAS for PDAC pathogenesis. An in-depth analysis of PDAC databases reveals various genetic alterations in the NF1 locus,...

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