Article
Long-read RNA-seq atlas of novel microglia isoforms elucidates disease-associated genetic regulation of splicing
2023-12-01
Abstract excerpt
Microglia, the innate immune cells of the central nervous system, have been genetically implicated in multiple neurodegenerative diseases. We previously mapped the genetic regulation of gene expression and mRNA splicing in human microglia, identifying several loci where common genetic variants in microglia-specific regulatory elements explain disease risk loci identified by GWAS. However, identifying genetic effec...
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Identifiers and source
- Literature Corpus work
- 794ae75c-1205-59de-a551-e2efc1f1bb04
- DOI
- 10.1101/2023.12.01.23299073