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Article

RNA splicing dynamics in CD8 T cells uncovers isoforms that impact T cell-mediated cancer immunotherapy

2025-09-11

Abstract excerpt

Immune checkpoint blockade has transformed cancer therapy, yet many patients fail to respond, and few new targets have emerged beyond PD-1 and CTLA-4. Alternative splicing dramatically diversifies the T cell proteome, but the functional roles of most isoforms remain unknown. Here we constructed the first single-cell splicing atlas of human CD8⁺ T cells, capturing dynamic isoform programs across activation and subs...

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Identifiers and source

Literature Corpus work
ae65001c-968f-5975-9848-231e5795b1cb
DOI
10.1101/2025.09.07.674706
Open publication

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