Article

Long-read single-cell RNA sequencing uncovers cell-type specific transcript regulation in COVID-19

2025-09-23

Abstract excerpt

SARS-CoV-2 infection leads to extensive host transcriptomic changes, but the role of alternative splicing in shaping the immune response remains underexplored. Here, we present the first application of long-read single-cell RNA sequencing on nasopharyngeal swabs from COVID-19 patients and healthy controls to resolve transcript-level changes across cell types. Our analysis identified major epithelial cell types and...

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Literature Corpus work: 46951053-9fa0-58c6-8340-dfce513eccba
DOI: 10.1101/2025.09.23.676511

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