Article
Revealing the Determinants of Widespread Alternative Splicing Perturbation in Cancer.
Cell reports - 17 Oct 2017
Li Yongsheng, Sahni Nidhi, Pancsa Rita, McGrail Daniel J, Xu Juan, Hua Xu, Coulombe-Huntington Jasmin, Ryan Michael, Tychhon Boranai, Sudhakar Dhanistha, Hu Limei, Tyers Michael, Jiang Xiaoqian, Lin Shiaw-Yih, Babu M Madan, Yi Song
Abstract excerpt
It is increasingly appreciated that alternative splicing plays a key role in generating functional specificity and diversity in cancer. However, the mechanisms by which cancer mutations perturb splicing remain unknown. Here, we developed a network-based strategy, DrAS-Net, to investigate more than 2.5 million variants across cancer types and link somatic mutations with cancer-specific splicing events. We...
Topics
- Alternative Splicing
- Gene Regulatory Networks
- Genetic Heterogeneity
- Humans
- Internet
- Mutation
- Neoplasms
- Phenotype