Article

Immune Isoform Atlas: Landscape of alternative splicing in human immune cells

2022-09-15

Abstract excerpt

<h4>Summary</h4> Alternative splicing events are a major causal mechanism for complex traits, but they have been understudied due to the limitation of short-read sequencing. Here, we generated a comprehensive full-length isoform annotation of human immune cells, Immune Isoform Atlas, by long-read sequencing for 29 cell subsets. Our atlas contained a number of unannotated transcripts and isoforms such as a read-th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 80f7c930-50d5-547c-8ec7-77207ee94737
DOI: 10.1101/2022.09.13.507708

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immune Isoform Atlas: Landscape of alternative splicing in human immune cellsDOI 10.1101/2022.09.13.507708Read

Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of <i>ERAP2</i> transcripts under balancing selectionSemantic proximity Read

Single-Cell Multi-Omics Dissects Transcript Isoform and Immune Repertoire Dynamics in Human ImmunosenescenceSemantic proximity Read

Decoding the human PBMC isonome: Isoform-level resolution with single-cell long-read transcriptomicsSemantic proximity Read

Surveying the landscape of RNA isoform diversity and expression across 9 GTEx tissues using long-read sequencing dataSemantic proximity Read

Splicing QTL analysis focusing on coding sequences reveals mechanisms for disease susceptibility loci.Semantic proximity Read

Isoform-level transcriptome Atlas of Macrophage ActivationSemantic proximity Read

Get Spliced: Uniting Alternative Splicing and Arthritis.Semantic proximity Read

Widespread intronic polyadenylation diversifies immune cell transcriptomesSemantic proximity Read

Long-read isoform sequencing reveals survival-associated splicing in breast cancerSemantic proximity Read

RNA splicing dynamics in CD8 T cells uncovers isoforms that impact T cell-mediated cancer immunotherapySemantic proximity Read

<i>SpliceImpactR</i> maps alternative RNA processing events driving protein functional diversitySemantic proximity Read

Splicing QTL analysis focusing on coding sequences reveals pathogenicity of disease susceptibility lociSemantic proximity Read