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Article

ISOTOPE: ISOform-guided prediction of epiTOPEs in cancer.

PLoS computational biology - 1 Sept 2021

Trincado Juan L, Reixachs-Solé Marina, Pérez-Granado Judith, Fugmann Tim, Sanz Ferran, Yokota Jun, Eyras Eduardo

Abstract excerpt

Immunotherapies provide effective treatments for previously untreatable tumors and identifying tumor-specific epitopes can help elucidate the molecular determinants of therapy response. Here, we describe a pipeline, ISOTOPE (ISOform-guided prediction of epiTOPEs In Cancer), for the comprehensive identification of tumor-specific splicing-derived epitopes. Using RNA sequencing and mass spectrometry for MHC-I...

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Identifiers

PMID: 34529669
DOI: 10.1371/journal.pcbi.1009411
PMCID: PMC8478223

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