Article

Intron retention regulates STAT2 function and predicts immunotherapy response in lung cancer

2025-08-19

Abstract excerpt

Immunotherapy benefits only a subset of lung cancer patients, and the molecular determinants of variable outcomes remain unclear. Using long-read RNA-sequencing we mapped the landscape of alternative RNA splicing in human primary lung adenocarcinomas. We identified over 180,000 full-length mRNA isoforms, more than half of which were novel and many of which occurred in immune-related genes, particularly within the...

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Literature Corpus work: 83a29643-6b0d-5732-8356-1093ba9c3c70
DOI: 10.1101/2025.08.19.671121

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