Article

SpliceMutr enables pan-cancer analysis of splicing-derived neoantigen burden in tumors

2023-05-26

Abstract excerpt

Aberrant alternative splicing can generate neoantigens, which can themselves stimulate immune responses and surveillance. Previous methods for quantifying splicing-derived neoantigens are limited by independent references and potential batch effects. Here, we introduce SpliceMutr, a bioinformatics approach and pipeline for identifying splicing derived neoantigens from tumor and normal data. SpliceMutr facilitates...

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Literature Corpus work: 569f616b-26ab-570c-9506-1c57e6888870
DOI: 10.1101/2023.05.26.542165

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