Article

IRIS: Big data-informed discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing

2019-11-15

Abstract excerpt

Aberrant alternative splicing (AS) is widespread in cancer, leading to an extensive but largely unexploited repertoire of potential immunotherapy targets. Here we describe IRIS, a computational platform leveraging large-scale cancer and normal transcriptomics data to discover AS-derived tumor antigens for T-cell receptor (TCR) and chimeric antigen receptor T-cell (CAR-T) therapies. Applying IRIS to RNA-Seq data fr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 072482e7-36b0-5f34-9eef-6cd8aae30e4a
DOI: 10.1101/843268

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

IRIS: Big data-informed discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicingDOI 10.1101/843268Read

ISOTOPE: ISOform-guided prediction of epiTOPEs in cancerSemantic proximity Read

Splicing neoantigen discovery with SNAF reveals shared targets for cancer immunotherapySemantic proximity Read

ISOTOPE: ISOform-guided prediction of epiTOPEs in cancer.Semantic proximity Read

Comprehensive profiling of cancer neoantigens from aberrant RNA splicingSemantic proximity Read

RNA splicing dynamics in CD8 T cells uncovers isoforms that impact T cell-mediated cancer immunotherapySemantic proximity Read

NovumRNA: accurate prediction of non-canonical tumor antigens from RNA sequencing dataSemantic proximity Read

Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in gliomaSemantic proximity Read

Targeting alternative splicing in cancer immunotherapySemantic proximity Read

SCAN-ACT: Adoptive T Cell Therapy Target Discovery Through Single-Cell TranscriptomicsSemantic proximity Read

Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in gliomaSemantic proximity Read

ScanNeo2: a comprehensive workflow for neoantigen detection and immunogenicity prediction from diverse genomic and transcriptomic alterationsSemantic proximity Read

Pervasive Intronic Polyadenylation Serves as a Potential Source of Cancer NeoantigensSemantic proximity Read