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Article

Roles and mechanisms of alternative splicing in cancer - implications for care.

Nature reviews. Clinical oncology - 1 Aug 2020

Bonnal Sophie C, López-Oreja Irene, Valcárcel Juan

Abstract excerpt

Removal of introns from messenger RNA precursors (pre-mRNA splicing) is an essential step for the expression of most eukaryotic genes. Alternative splicing enables the regulated generation of multiple mRNA and protein products from a single gene. Cancer cells have general as well as cancer type-specific and subtype-specific alterations in the splicing process that can have prognostic value and contribute to every...

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PMID: 32303702
DOI: 10.1038/s41571-020-0350-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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