Article
Roles and mechanisms of alternative splicing in cancer - implications for care.
Nature reviews. Clinical oncology - 1 Aug 2020
Bonnal Sophie C, López-Oreja Irene, Valcárcel Juan
Abstract excerpt
Removal of introns from messenger RNA precursors (pre-mRNA splicing) is an essential step for the expression of most eukaryotic genes. Alternative splicing enables the regulated generation of multiple mRNA and protein products from a single gene. Cancer cells have general as well as cancer type-specific and subtype-specific alterations in the splicing process that can have prognostic value and contribute to every...
Topics
- Alternative Splicing
- Humans
- Introns
- Mutation
- Neoplasms
- RNA Precursors
- RNA Splicing
- RNA, Messenger