ISOTOPE: ISOform-guided prediction of epiTOPEs in cancer

Abstract excerpt

Immunotherapies provide effective treatments for previously untreatable tumors and identifying tumor-specific epitopes can help elucidate the molecular determinants of therapy response. Here, we describe a pipeline, ISOTOPE (ISOform-guided prediction of epiTOPEs In Cancer), for the comprehensive identification of tumor-specific splicing-derived epitopes. Using RNA sequencing and mass spectrometry for MHC-I associa...

Topics

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• Alternative Splicing
• Carcinoma, Small Cell
• Epitopes
• Histocompatibility Antigens Class I
• Immunotherapy
• Models, Immunological
• RNA-Seq
• RNA Splicing

Identifiers and source

Literature Corpus work

7b5d9384-344d-5e36-8a63-1dccd223bd3d

DOI

10.1101/2020.06.18.159244