Article

Long-read isoform sequencing reveals survival-associated splicing in breast cancer

2020-11-11

Abstract excerpt

<h4>Summary</h4> Tumors display widespread transcriptome alterations, but the full repertoire of isoform-level alternative splicing in cancer is not known. We developed a long-read RNA sequencing and analytical platform that identifies and annotates full-length isoforms, and infers tumor-specific splicing events. Application of this platform to breast cancer samples vastly expands the known isoform landscape of b...

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Literature Corpus work: bf50e7bf-c140-58b4-877b-9ad6e2b8abe2
DOI: 10.1101/2020.11.10.376996

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