Article

SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairment

2024-04-04

Abstract excerpt

Decreased dendritic complexity and impaired synaptic function are strongly linked to cognitive decline in Alzheimer’s disease (AD), and precede the emergence of other neuropathological traits that establish a harmful cycle exacerbating synaptic dysfunction. SFRP1, a glial-derived protein regulating cell-cell communication, is abnormally elevated in the brain of AD patients and related mouse models already at early...

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Literature Corpus work: add5ff74-cee7-551c-b1a4-3caea3811720
DOI: 10.1101/2024.04.04.588100

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