Article

AETA peptide contributes to Alzheimer’s disease signature of synapse dysfunction

2025-08-25

Abstract excerpt

Alzheimer’s disease (AD), the leading cause of dementia, is characterized by early synaptic dysfunction that precedes overt cognitive decline. While amyloid-β and Tau remain central to AD pathogenesis, molecular triggers of synapse weakening remain unclear. Here, we investigated AETA, a novel brain-secreted peptide derived from amyloid precursor protein (APP), as a potential mediator of synapse dysfunction in AD....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c441845a-1be1-530c-b34d-330b90f82aa5
DOI: 10.1101/2025.08.22.671719

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

AETA peptide contributes to Alzheimer’s disease signature of synapse dysfunctionDOI 10.1101/2025.08.22.671719Read

AETA peptide drives Alzheimer’s disease signature of synapse dysfunctionSemantic proximity Read

Differential neural circuit vulnerability to β-amyloid and tau pathologies in novel Alzheimer’s disease miceSemantic proximity Read

Astrocyte transcriptomic analysis identifies glypican 5 downregulation as a contributor to synaptic dysfunction in Alzheimer’s disease modelsSemantic proximity Read

Sex‐biased hippocampal pathology in the 5XFAD mouse model of Alzheimer's disease: A multi‐omic analysisSemantic proximity Read

Alzheimer's disease: Aβ, tau and synaptic dysfunctionSemantic proximity Read

Transcriptomic analysis reveals sex-specific patterns in the hippocampus in Alzheimer’s diseaseSemantic proximity Read

Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's diseaseSemantic proximity Read

Reducing tau ameliorates behavioural and transcriptional deficits in a novel model of Alzheimer’s diseaseSemantic proximity Read

Sex‐specific accelerated decay in time/activity‐dependent plasticity and associative memory in an animal model of Alzheimer's diseaseSemantic proximity Read

Tip60 protects against amyloid-β peptide-induced transcriptomic alterations via different modes of action in early versus late stages of neurodegenerative progressionSemantic proximity Read

Epigenetic regulation of synaptic disorder in Alzheimer’s diseaseSemantic proximity Read

CD8+ T-cells infiltrate Alzheimer’s disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic miceSemantic proximity Read