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APPsα Rescues Tau-Induced Synaptic Pathology

6 Jun 2022

Abstract excerpt

Alzheimer9s disease (AD) is histopathologically characterized by Aβ plaques and the accumulation of hyperphosphorylated Tau species, the latter also constituting key hallmarks of primary tauopathies. Whereas Aβ is produced by amyloidogenic APP processing, APP processing along the competing nonamyloidogenic pathway results in the secretion of neurotrophic and synaptotrophic APPsα. Recently, we demonstrated that...

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PMID: 35667850
DOI: 10.1523/jneurosci.2200-21.2022

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