Article

C5aR1 signaling promotes region and age dependent synaptic pruning in models of Alzheimer’s Disease

2023-10-02

Abstract excerpt

<h4>INTRODUCTION</h4> Synaptic loss is a hallmark of Alzheimer’s disease (AD) that correlates with cognitive decline in AD patients. Complement-mediated synaptic pruning has been associated with this excessive loss of synapses in AD. Here, we investigated the effect of C5aR1 inhibition on microglial and astroglial synaptic pruning in two mouse models of AD. <h4>METHODS</h4> A combination of super-resolution and...

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Literature Corpus work: 2cebbd87-7dc1-5f10-b945-0c7afef080ed
DOI: 10.1101/2023.09.29.560234

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