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Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein

15 Nov 2023

Abstract excerpt

Abstract Background Progression of Alzheimer’s disease leads to synapse loss, neural network dysfunction and cognitive failure. Accumulation of protein aggregates and brain immune activation have triggering roles in synaptic failure but the neuronal mechanisms underlying synapse loss are unclear. On the neuronal surface, cellular prion protein (PrP C ) is known to be a high-affinity binding site for Amyloid-β...

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PMID: 37968719
DOI: 10.1186/s13195-023-01345-z

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