Article
Proteomics, ultrastructure, and physiology of hippocampal synapses in a fragile X syndrome mouse model reveal presynaptic phenotype.
The Journal of biological chemistry - 22 Jul 2011
Klemmer Patricia, Meredith Rhiannon M, Holmgren Carl D, Klychnikov Oleg I, Stahl-Zeng Jianru, Loos Maarten, van der Schors Roel C, Wortel Joke, de Wit Heidi, Spijker Sabine, Rotaru Diana C, Mansvelder Huibert D, Smit August B, Li Ka Wan
Abstract excerpt
Fragile X syndrome (FXS), the most common form of hereditary mental retardation, is caused by a loss-of-function mutation of the Fmr1 gene, which encodes fragile X mental retardation protein (FMRP). FMRP affects dendritic protein synthesis, thereby causing synaptic abnormalities. Here, we used a quantitative proteomics approach in an FXS mouse model to reveal changes in levels of hippocampal synapse proteins....
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