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Astrocyte transcriptomic analysis identifies glypican 5 downregulation as a contributor to synaptic dysfunction in Alzheimer’s disease models

2024-10-31

Abstract excerpt

<h4>ABSTRACT</h4> Synaptic dysfunction is an early feature in Alzheimer’s disease (AD) and correlates with cognitive decline. Astrocytes are essential regulators of synapses, impacting synapse formation, maturation, elimination and function. To understand if synapse-supportive functions of astrocytes are altered in AD, we used astrocyte BacTRAP mice to generate a comprehensive dataset of hippocampal astrocyte tra...

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Literature Corpus work: 26002490-dd2a-59eb-a479-f65c4230d27e
DOI: 10.1101/2024.10.30.621182

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