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Article

Longitudinal characterization of behavioral, morphological and transcriptomic changes in a tauopathy mouse model

3 Nov 2023

Abstract excerpt

Neurodegenerative disorders, such as Alzheimer's disease (AD), have the gradual onset of neurobiological changes preceding clinical diagnosis by decades. To elucidate how brain dysfunction proceeds in neurodegenerative disorders, we performed longitudinal characterization of behavioral, morphological, and transcriptomic changes in a tauopathy mouse model, P301S transgenic mice. P301S mice exhibited cognitive...

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PMID: 37925173
DOI: 10.18632/aging.205057

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