Article

Early-life stress exposure impacts the hippocampal synaptic proteome in a mouse model of Alzheimer’s disease: age- and pathology-dependent effects on mitochondrial proteins

2023-04-20

Abstract excerpt

Epidemiological evidence indicates that early life stress (ES) exposure increases the risk for later-life diseases, such as Alzheimer’s disease (AD). Accordingly, we and others have shown that ES aggravates the development of, and response to, amyloid-beta (Aβ) pathology in animal models. Moreover, ES-exposed transgenic APP/PS1 mice display deficits in both cognitive flexibility and synaptic function. As the mecha...

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Literature Corpus work: 40b50317-4c9c-5925-97da-d450c7b5ab1e
DOI: 10.1101/2023.04.20.537660

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