Article
Genome sequencing of normal cells reveals developmental lineages and mutational processes.
Nature - 18 Sept 2014
Behjati Sam, Huch Meritxell, van Boxtel Ruben, Karthaus Wouter, Wedge David C, Tamuri Asif U, Martincorena Inigo, Petljak Mia, Alexandrov Ludmil B, Gundem Gunes, Tarpey Patrick S, Roerink Sophie, Blokker Joyce, Maddison Mark, Mudie Laura, Robinson Ben, Nik-Zainal Serena, Campbell Peter, Goldman Nick, van de Wetering Marc, Cuppen Edwin, Clevers Hans, Stratton Michael R
Abstract excerpt
The somatic mutations present in the genome of a cell accumulate over the lifetime of a multicellular organism. These mutations can provide insights into the developmental lineage tree, the number of divisions that each cell has undergone and the mutational processes that have been operative. Here we describe whole genomes of clonal lines derived from multiple tissues of healthy mice. Using somatic base...
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