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Article

Lineage tracing in human tissues.

The Journal of pathology - 1 Jul 2022

Gabbutt Calum, Wright Nicholas A, Baker Ann-Marie, Shibata Darryl, Graham Trevor A

Abstract excerpt

The dynamical process of cell division that underpins homeostasis in the human body cannot be directly observed in vivo, but instead is measurable from the pattern of somatic genetic or epigenetic mutations that accrue in tissues over an individual's lifetime. Because somatic mutations are heritable, they serve as natural lineage tracing markers that delineate clonal expansions. Mathematical analysis of the...

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Identifiers

PMID: 35415852
DOI: 10.1002/path.5911
PMCID: PMC9253082

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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