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Article

Utilizing DNA mutations to trace epithelial cell lineages in human tissues.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Zeki Sebastian, Graham Trevor A, McDonald Stuart A C

Abstract excerpt

Epithelial stem cells are typically multipotential and are likely the cell of origin of epithelial cancers. Tracing the expansion of a single stem cell's progeny, identifying and characterizing these cells in human tissue has proven difficult. Invasive labeling studies, which have led to much success in model organisms, are impracticable in humans. Instead, human studies must rely upon naturally occurring clonal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22914949
DOI: 10.1007/978-1-61779-980-8_22

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