Article
Different mutational rates and mechanisms in human cells at pregastrulation and neurogenesis.
Science (New York, N.Y.) - 2 Feb 2018
Bae Taejeong, Tomasini Livia, Mariani Jessica, Zhou Bo, Roychowdhury Tanmoy, Franjic Daniel, Pletikos Mihovil, Pattni Reenal, Chen Bo-Juen, Venturini Elisa, Riley-Gillis Bridget, Sestan Nenad, Urban Alexander E, Abyzov Alexej, Vaccarino Flora M
Abstract excerpt
Somatic mosaicism in the human brain may alter function of individual neurons. We analyzed genomes of single cells from the forebrains of three human fetuses (15 to 21 weeks postconception) using clonal cell populations. We detected 200 to 400 single-nucleotide variations (SNVs) per cell. SNV patterns resembled those found in cancer cell genomes, indicating a role of background mutagenesis in cancer. SNVs with a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.