Article

DNA Replication Modulates R-loop Levels to Maintain Genome Stability

2017-06-26

Abstract excerpt

<h4>Summary</h4> Conflicts between transcription and replication are a potent source of DNA damage. The transcription machinery has the potential to aggravate such conflicts by generating co-transcriptional R-loops as an additional barrier to replication fork progression. Here, we investigate the influence of conflict orientation and R-loop formation on genome stability in human cells using a defined episomal sys...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ad38a3ab-dbad-5ead-8e06-e1bf3bae3465
DOI: 10.1101/155978

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DNA Replication Modulates R-loop Levels to Maintain Genome StabilityDOI 10.1101/155978Read

WRNIP1 prevents transcription-associated genomic instabilitySemantic proximity Read

Low replication stress leads to specific replication timing advances associated to chromatin remodelling in cancer cellsSemantic proximity Read

DNA replication stress: Causes, resolution and diseaseSemantic proximity Read

Transcription drives DNA replication initiation and termination in human cellsSemantic proximity Read

Protein-mediated stabilization and nicking of the non-template DNA strand dramatically affect R-loop formation <i>in vitro</i>Semantic proximity Read

Replication Stress, Genomic Instability, and Replication Timing: A Complex Relationship.Semantic proximity Read

ATR and TopBP1 oppose to control dormant origin building, providing a first defence against replication stressSemantic proximity Read

Impediments to replication fork movement: stabilisation, reactivation and genome instability.Semantic proximity Read

Transcription-Coupled Repair and R-Loop Crosstalk in Genome StabilitySemantic proximity Read

Spotlight on the Replisome: Aetiology of DNA Replication-Associated Genetic Diseases.Semantic proximity Read

Origin of Genome Instability and Determinants of Mutational Landscape in Cancer Cells.Semantic proximity Read

H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress.Semantic proximity Read