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Article

Origin of Genome Instability and Determinants of Mutational Landscape in Cancer Cells.

Genes - 21 Sept 2020

Mehrotra Sonam, Mittra Indraneel

Abstract excerpt

Genome instability is a crucial and early event associated with an increased predisposition to tumor formation. In the absence of any exogenous agent, a single human cell is subjected to about 70,000 DNA lesions each day. It has now been shown that physiological cellular processes including DNA transactions during DNA replication and transcription contribute to DNA damage and induce DNA damage responses in the...

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Identifiers

PMID: 32967144
DOI: 10.3390/genes11091101
PMCID: PMC7563369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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