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Article

Impediments to replication fork movement: stabilisation, reactivation and genome instability.

Chromosoma - 1 Mar 2013

Lambert Sarah, Carr Antony M

Abstract excerpt

Maintaining genome stability is essential for the accurate transmission of genetic material. Genetic instability is associated with human genome disorders and is a near-universal hallmark of cancer cells. Genetic variation is also the driving force of evolution, and a genome must therefore display adequate plasticity to evolve while remaining sufficiently stable to prevent mutations and chromosome rearrangements...

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PMID: 23446515
DOI: 10.1007/s00412-013-0398-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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